科研项目 （近五年） | [1] 国家自然科学基金委员会, 面上项目, 8257080410, 维生素 A 代谢产物 ATRA 通过 PPARγ-AP-1 轴调控SFTSV感染所致全身性炎性反应的分子机制研究, 2026-01-01 至 2029-12-31, 53 万元, 在研, 主持 [2] 中华人民共和国科学技术部, 国家重点研发计划, 2022YFD1800804, 猪重要病毒病新型基因工程疫苗研制, 2022-12 至 2025-12, 400（140）万元, 在研, 主持 [3] 国家自然科学基金委员会, 面上项目, 32172864, 双歧杆菌通过代谢产物精胺介导宿主 I 型干扰素抗病毒天然免疫分子机制的研究, 2022-01-01 至 2025-12-31, 58 万元, 在研, 主持 [4] 国家自然科学基金委员会, 联合基金项目, U21A20261, 吉林省畜禽重要疫病病原与宿主肠道微生态互作及抗感染免疫机制研究, 2022-01-01 至 2025-12-31, 266（100）万元, 在研, 参与 |
主要论著、 代表性论文 | [1] Jinyan Xie; Hao Li; Xiaoai Zhang; Tong Yang; Mengjia Yue; Yunfa Zhang; Shuxian Chen; Ning Cui; Chun Yuan; Jingyun Li; Shu Jeffrey Zhu; Wei Liu ; Akkermansia muciniphila protects mice against an emerging tick-borne viral pathogen, Nature Microbiology, 2023, 8(1): 91-106 (共同通讯作者，IF5=20.70) [2] Yanan Zhang; Shuyu Tu; Xingwei Ji; Jianan Wu; Jinxin Meng; Jinsong Gao; Xian Shao; Shuai Shi; Gan Wang; Jingjing Qiu; Zhuobiao Zhang; Chengang Hua; Ziyi Zhang; Shuxian Chen; Li Zhang; Shu Jeffrey Zhu; Dubosiella newyorkensis modulates immune tolerance in colitis via the L-lysine-activated AhRIDO1-Kyn pathway, Nature Communications, 2024, 15(1333): 1-19 (唯一通讯作者，IF5=15.70) [3] Yanan Zhang , Shuyu Tu, Xian Shao, Jinxin Meng, Zhuobiao Zhang, Wei Wei, Xuping Jing, Zhewen Qin, Jianan Wu, Weilv Xu, Bofei Dong, Jinsong Gao, Aijuan Qu, Shuxian Chen, Li Zhang, Peng Gong, Bo Shan, Hui Shi and Shu Jeffrey Zhu; Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing through PPARα, Nature Communications, 2026. (已录用,第一通讯作者，IF5=15.70) [4] Yanan Zhang, Jinxin Meng, Shuyu Tu, Linlin Ma, Xinya Zhao, Jinsong Gao, Jianan Wu, Weilv Xu, Shuxian Chen, Hairong Cheng, Li Zhang, and Shu Jeffrey Zhu.Supplementary information for A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a Hopx-associated program,Nature Communications, 2026. (已录用,第一通讯作者，IF5=15.70) [5] Gan Wang; Jingtianyi Liu; Yanan Zhang; Jinyan Xie; Shuxian Chen; Yuhua Shi; Fushan Shi; Shu Jeffrey Zhu; Ginsenoside Rg3 enriches SCFA-producing commensal bacteria to confer protection against enteric viral infection via the cGAS-STING-type I IFN axis, The ISME Journal, 2023, 17(12): 2426-2440 (唯一通讯作者，IF5=12.50) [6] Yaqing Zhang, Bin Wang, Yongle Yang, Jinxin Meng, Mengdi Zhang, Yike Li, Bo Dong, Yanan Zhang, Bowen Liu, Dong Yang, Chunmiao Ji, Yaowei Huang, Shu Jeffrey Zhu; A gut microbiota-bile acid axis inhibits infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N. iMeta, 2025, 4: e70061. (共同通讯作者，IF5=33.20) [7] Qi-Yue Yang; Yong-Le Yang; Yi-Xing Tang; Pan Qin; Gan Wang; Jin-Yan Xie; Shu-Xian Chen; Chan Ding; Yao-Wei Huang; Shu Jeffrey Zhu; Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids, PLoS Pathogens, 2022, 18(6): e1010620 (唯一通讯作者，IF5=5.40) |
